Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury
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چکیده
منابع مشابه
A novel antioxidant non-steroidal anti-inflammatory agent protects rat liver against ischemia-reperfusion injury.
Liver ischemia followed by reperfusion is an important and common clinical event. A major mechanism is leukocyte adhesion to endothelium followed by release of reactive oxygen metabolites. The aim of this study was to determine the effects of a novel antioxidant ethylenediamine derivative with anti-inflammatory properties (compound IA) on an imitated clinical setting of acute hepatic ischemia-r...
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Objective(s): Neutrophils play an important role in ischemia/reperfusion (IR) induced skeletal muscle injury. Microtubules are required for neutrophil activation in response to various stimuli. This study aimed to investigate the effects of colchicine, a microtubule-disrupting agent, on skeletal muscle IR injury in a rat hindlimb ischemia model. Materials and Methods: Twenty-one Sprague-Dawley ...
متن کاملVinpocetine protects liver against ischemia-reperfusion injury.
Hepatic ischemia-reperfusion (IR) injury is a clinical problem that leads to cellular damage and organ dysfunction mediated mainly via production of reactive oxygen species and inflammatory cytokines. Vinpocetine has long been used in cerebrovascular disorders. This study aimed to explore the protective effect of vinpocetine in IR injury to the liver. Ischemia was induced in rats by clamping th...
متن کاملGrape seed protects cholestatic rats liver from ischemia/reperfusion injury.
PURPOSE To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/d...
متن کاملSmad1 protects cardiomyocytes from ischemia-reperfusion injury.
BACKGROUND We previously reported that bone morphogenetic protein 2 (BMP2) protected against apoptosis of serum-deprived cardiomyocytes via induction of Bcl-xL through the Smad1 pathway. To investigate whether Smad1 signaling promotes cell survival in the adult heart, we subjected transgenic mice with cardiac-specific overexpression of smad1 gene (Smad1TG) to ischemia-reperfusion (I/R) injury. ...
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ژورنال
عنوان ژورنال: Transplant International
سال: 1997
ISSN: 0934-0874,1432-2277
DOI: 10.1007/s001470050019